Peg MGF Consolidated Information

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The water-soluble peptide Peg MGF is a combination of Polyethylene glycol and the repair factor MGF, also known as Mechano Growth Factor.  Its molecular mass is 2867.2, and its molecular formula is C121H200N42O39.

Peg MGF Basics

Scientific study that has been conducted on animal test subjects has determined that Peg MGF’s functionality is primarily tied to boosting the efficiency in which muscular and skeletal tissue can be grown and repaired.  Specifically, its functionality can be focused in on the secretion of mechano growth factor; an isoform that has been shown to play a key role in the regulation of muscle and tissue growth amongst animal test subjects.  The downside of this secretion is that it has a rapid half-life, which in turn means that its overall effectiveness as it relates to its overall functionality is limited.

However, it has been noted through scientific study of animal test subjects that Peg MGF’s functionality allows for an extension of this half-life by way of PEGylaton; a process that enable a covalent attachment to form around the secretion, thus performing a barrier.  This barrier enables the secretion to maintain a state of design integrity within the bloodstream for a longer period of time without breaking down.  This then enables a greater period of stability which also allows for a boost in the secretion’s functionality to occur.  Because the peptide is linked to manners concerning the growth and repair of muscular and skeletal tissue, this means that the presence of Peg MGF allows for a promoted level of muscle and tissue growth and repair to occur, thus leading to an increased level of homeostasis for the animal test subject.

A Boost in Processes

Because Peg MGF has shown a capacity for elevating the functionality of mechano growth factor, scientific study based on animal test subjects has been able to hone in on a few bodily processes that could hypothetically increase as a result of the peptide’s inherent functionality.

For example, it is thought that Peg MGF could enable a promotion of skeletal muscle regeneration.  This has been linked to Peg MGF’s ability to extend the half-life of the secretion related to mechano growth factor.  Because of this extension, it is thought that the secretion’s anabolic ability in relation to muscular and tissue repair could occur on a more effective and efficient manner.

Additionally, it is thought that Peg MGF’s ability to extend the half-life of mechano growth factor enables a longer window of time for the secretion’s processes relating to the repair of muscle fiber and skeletal tissue can be expressed.  Because of this extended time interval, it is thought that the presence of the peptide can translate into an animal test subject to experience a more rapid mode of recovery from an injury.

Also, it is also been proposed that Peg MGF’s functionality can allow for an enhanced means of bone density to occur.  Scientific study based on animal test subjects has determined that the presence of the peptide has allowed for bone mineral to be produced more efficiently.  As such, it has been theorized that Peg MGF can enable an animal test subject to experience a boost in the density of its bones on a more efficient basis.  This process in turn enables the test subject to be better protected from breaks, fractures, or other bone-related injuries.

Peg MGF and Ischemic Injury

According to scientific study on animal test subjects, it has been determined that Peg MGF could be a possible aid in bringing about stabilization of cellular response to certain types of ischemic injury; a condition that is brought about by a restriction of blood supply to tissues, thus causing a shortage of the oxygen and glucose needed for cellular metabolism.  Some of these ischemic injuries include:

  • Stroke
  • Angina pectoris
  • Cardiac arrest due to a heart attack
  • Insufficient oxygen delivered to an effected area in the wake of a traumatic injury.

Scientific study that has been conducted on animal test subjects has noted that the reason that Peg MGF can be a theoretic aid in relation to ischemic injury is due to the fact that it enables a more efficient manner of secretions related to bodily repair to flow through the bloodstream.  Hence, this would lessen the instances in which the restriction that is associated with ischemic injury can occur.

For Scientific Research Only

Even though there has been an extensive amount of research and study conducted in relation to Peg MGF and its overall functionality, operational mechanics, and theorized benefits, it needs to be noted that all of the research that has been conducted has been exclusively built around the scientific study based on animal test subjects.  The peptide is only intended for the use of scientific study at this point in time.  Because of this, any findings or observations that relate to Peg MGF’s overall functionality, mechanics, or theoretical benefits, should only be contained to the strict confines of a controlled environment such as a laboratory or a medical research facility.

The Science Behind PT-141 (Bremelanotide)

PT-141 (Bremelanotide)

PT-141 (Bremelanotide) is a research cyclic peptide whose scientific study on animal test subjects is primarily tied to potentially positive effects relating to hemorrhagic shock and reperfusion injury.  It contains a molecular mass of 1025.2, and carries a molecular formula of C50H68N14O10.  It also has a half-life of 120 minutes.

PT-141 (Bremelanotide) and Melanocortin

According to scientific study that has been conducted on animal test subjects, it has been determined that PT-141 (Bremelanotide)’s functional processes enables it to work with melanocortin receptors.  These are the proteins that are paired to G-proteins and signaled through intracellular cyclic adenosine monophosphate.  Specifically, PT-141 (Bremelanotide) has been shown to target melanocortin receptors MC3-R and MC4-R in animal test subjects’ central nervous system.  These particular receptors function to block and control the transmission of specific signals from the brain to the parts of the central nervous system that tie to negative body functions such as inflammation or restriction of blood flow.  Ultimately, this type of receptor activation has been shown to result in inflammation modulation as well as an inhibition of ischemia; the condition marked by restrictions in the blood supply due to various factors related to blood vessels.

Because of this functionality, scientific study that has been based on animal test subjects has determined that PT-141 (Bremelanotide) can work to curb bodily irritation that can be caused by various pathogens and irritants.  It has also been determined that PT-141 (Bremelanotide) can minimize the damage or dysfunction of blood vessels and associated tissues that could occur as a result of an ischemic episode.

PT-141 (Bremelanotide) and Hemorrhagic Shock Management

Scientific study that has been based on animal test subjects relating to PT-141 (Bremelanotide) has determined that the peptide could be useful in managing hemorrhagic shock, a potentially serious condition that is marked by decreased tissue perfusion.  The onset of this condition results in an inadequate delivery of the oxygen and nutrients that are essential for proper cellular functionality.

This condition manifests itself through four different classes of shock:

  • Neurogenic
  • Cardiogenic
  • Hypovolemic
  • Vasogenic (also known as septic)

These varying shock classifications can result in a host of potentially dangerous scenarios in animal test subjects.  These can include serious issues related to the cardiovascular system such as a decreased cardiac output or a decrease in pulse pressure.

It has been determined through the scientific study of animal test subjects that PT-141 (Bremelanotide) can aid in the stimulation of neural reflexes in order to increase sympathetic outflow to the heart and other organs that may otherwise slow down dramatically or even stop outright as a result of hemorrhagic shock.  This stimulation consists of various factors like an elevated heart rate, vasoconstriction, and a redistribution of blood flow away from organs that an animal test subject’s body would otherwise view as non-vital, like kidneys or skin.

PT-141 (Bremelanotide) and Reperfusion Injury

Scientific study based on animal test subjects has also determined that PT-141 (Bremelanotide) could aid in lessening the repercussions of reperfusion injury; a condition that is marked by tissue damage caused by the blood supply reentering into the tissue after an ischemic episode such as a stroke.  The lack of nutrients and oxygen from blood during an ischemic period generates a condition in which the restoration of circulation results in oxidative damage and inflammation via oxidative stress as opposed to the restoration of proper functionality.  This type of injury plays a key role to the brain’s reaction to an ischemic episode, which could lead to strokes, cardiac arrest, and a host of other traumatic injuries.  Additionally, this particular type of injury can present in other forms of brain failure, such s the moments following the reversal of cardiac arrest.

According to scientific study based on animal test subjects, it has been shown that PT-141 (Bremelanotide) works neurologically in order to lower the inhibitions associated with blood flow restriction to tissues resulting from the brain’s reactionary process regarding an ischemic episode.  This would then lessen or even halt the resultant damage that could otherwise come as the result of a limitation of blood flow in the areas that would be potentially affected.

Purely for Scientific Research

Despite the fact that there has been plenty of research on PT-141 (Bremelanotide) in relation to how it functions and the benefits that can be derived from such functionality, it should be emphasized that the peptide is still just intended for scientific study at this point in time.  All matters of research relating to the way in which PT-141 (Bremelanotide) operates has all been culled from scientific study on animal test subjects.  Because of this, any findings or observations relating to PT-141 (Bremelanotide)’s overall functionality, mechanics, benefits, should exclusively be the product of study performed in a strictly contained environment such as a medical research facility or a laboratory.

IGF-1 LR3 Facts

American Made IGF-1 LR3

IGF-1 LR3 is a non-glycosylated peptide that has a molecular structure of C990H1528N262O300S7 and a molecular weight of 9200.  Its structure consists of 83 amino acids, and it can occasionally go by the name of Long r3 igf-1.

IGF-LR3’s Interaction with Organs

It has been determined that IGF-LR3’s overall operational mechanics can be linked to two specific organs according to scientific study based on animal test subjects:

  • The liver – This internal organ is chiefly responsible for the regulation and control of various processes as they relate to the detoxification, digestion, and protein synthesis that happen within the body of an animal test subject.
  • The pancreas – This internal organ, which is glandular in nature, is a vital member of the endocrine system. It has been shown to pay an essential role in the production of hormones as they relate to an animal test subject’s functionality.

Specifically, scientific study based on animal test subjects has determined that the functionality of IGF-LR3 can be linked to specific secretions that are expressed by these respective organs.

The first of these secretions is insulin.  This particular secretion originates from the pancreas and is more or less charged with governing the proper level of glucose absorption from the bloodstream by cells found in the liver, skeletal muscles, and fat tissues of animal test subjects.  Further studies have shown that IGF-LR3 can further aid in this process by enabling a boost of transport regarding the secretion throughout the animal test subject’s body.

The second of these secretions is IGF-1, also known as Insulin-like Growth Factor-1 or Somatomedin C.  This secretion originates from the liver and has been noted to be highly anabolic.  What this means is, it can play a vital role in the building and the repairing of muscular and skeletal tissue by way of a series of chemical reactions of complex molecules.  The only problem with this particular secretion is that it has a limited effectiveness, as its half-life only lasts for about 20 minutes.  However, studies have indicated that IGF-LR3’s operational mechanics are such that they can influence a dramatic rise in IGF-1’s half-life; a rise that extends it to more than 20 hours.  This in turn allows the abilities that are tied to the secretion to be effective for a substantially longer period of time.

The Results of Such Interaction

Because of the way in which IGF-LR3 interacts with insulin and IGF-1, scientific study that has been based on animal test subjects has determined that the presence of the peptide could conceivably be linked to several elevated processes that are associated with the test subjects’ overall functionality.  These processes have been said to include a boost in protein synthesis, an increase in RNA synthesis, an elevated means of glucose and amino acids on a cellular level, and a lowering of overall protein degradation.

These processes ultimately have led scientific study that has been based on animal test subjects to derive a host of theorized benefits as they relate to IGF-LR3.  The primary benefit that has been hypothetically linked relates to a boosted means of muscle retention.  This concept is related to the peptide’s ability to extend the half-life of IGF-1.  Because this boost in half-life also means a boost in the anabolic properties that IGF-1 has been shown to exhibit, it is thought that the presence of the peptide could allow an animal test subject to experience an improved level of homeostasis regarding muscle tone and muscle shape.  This process has also led to the notion that the peptide could play a key role in accelerating the rate at which an animal test subject can recover from injury.

Another benefit that has been conceivably linked to the peptide relates to a boosted measure of endurance.  Because of the boost in IGF-1’s anabolic properties that IGF-LR3 has been said to cause, it is thought that the boosted process that it influences could enable an animal test subject to experience an elevated level of performance and stamina before the negative effects of fatigue kick in.

Only for Research Purposes

Despite the fact that an extensive amount of study and research has been done in order to pinpoint the overall functionality of IGF-LR3, up to and including the ways in which it can promote various process, it needs to be emphasized that all of the research that has been conducted in conjunction with the peptide has only been constructed around scientific studies that have been based on animal test subjects.  Furthermore, the current use of the peptide is solely intended for scientific research purposes and nothing more.  As such, any findings or observations relating to IGF-LR3’s overall functionality the determinations that can be derived from such observations should be exclusively contained to a strictly controlled environment such as a laboratory or a medical research facility.