All About AICAR


What is AICAR?

The peptide AICAR is an intermediate within the generation of inosine monophosphate, a nucleotide monophosphate that plays a vital role in the regulation of metabolism.  It contains a molecular weight of 338.211, and has a molecular formula of C9H15N4O8P.  It can sometimes be known by several different names, including:

  • AICA Ribonucleotide
  • ZMP
  • Acadesine
  • 5-aminoimidozloe-4 carboxamide ribonucleotide

AICAR on a Cellular Level

According to scientific study based on animal test subjects, it has been determined that AICAR works on a cellular level by infiltrating cardiac cells.  Once these cells have been entered, the peptide continues its functionality by prohibiting the creation of the enzymes adenosine kinase (ADK) and adenosine deaminase (ADA); two enzymes that regulate glucose intake and energy conversion.  Because AICAR has been shown to block these two enzymes from happening, it has been determined that the presence of the peptide can lead to an elevated level of which glucose is synthesized by the cellular unit, as well as a boosted rate in which energy can be converted.  Additionally, these studies also show that AICAR has an ability to block apotosis; that is, the process of programmed cell death.

What This Cellular Level Interaction Means

Because of AICAR’s ability to in essence work with cardiac cells to improve glucose intake and energy production, scientific study based on animal test subjects has derived several positive associations that tie into the peptide’s mechanics.

The primary association that has been ascertained relates to AICAR’s possible ability to aid in prevention and/or treatment of issues related to cardiac ischemic injury.  In general terms, an ischemic injury is something that is caused by a constraint of blood supply to tissues, which in turn causes insufficient levels of glucose and oxygen to occur; this causes a breach in the animal test subjects’ ability to conduct proper cellular metabolism, which is essential for tissue survival.  While an ischemic condition can manifest itself in various conditions such as thrombosis, vasoconstriction, or embolism, a cardiac ischemic injury is one that directly correlates to the myocardium, the muscle that is better known as the heart.  This condition can lead to cardiac arrest, and could be signaled by a condition known as angina pectoris, otherwise known as a lack of sufficient blood flow to the brain.

AICAR’s overall mechanics are such that scientific study based on animal test subjects has determined that it can possibly help in preventing blood flow restriction; this prevention could aid in stopping an ischemic episode from happening even before it begins.  It is also thought that ACAR’s properties can make in an effective aid in treating an animal test subject in the event of a heart attack that is brought on by an ischemic episode.  This deduction is specifically tied to the peptide’s ability to promote an elevated level of blood flow to the heart muscle, thus allowing a greater instance of stabilization as the animal test subject recovers.

AICAR’s functionality has also led scientific study on animal test subjects to determine that the peptide can allow for an increased endurance to occur.  It is though that AICAR can do this because the of the peptide’s ability to enable blood to flow through an animal test subject’s circulatory system more freely.  This, then, enables a more efficient means of receiving energy, thus allowing for an animal test subject to experience a boosted level of energy over a longer stretch of time.

Additionally, it has been noted that AICAR’s functionality could allow for a boosted rate at wich adipose tissue (also known as body fat) can get broken down.  This elevated process is due to the notion that AICAR can enable a more efficient means of energy conversion.  Because of this boosted rate, the animal test subject’s body will respond by increasing the rate it can burn through adipose tissue in order to compensate for the heightened energy demands.  It should be noted that this uptick in breaking down adipose tissue is only effective if the animal test subject sticks to a controlled, regulated diet and does not increase its elevated intake of food.

Only for Research Purposes

Despite the fact that an extensive amount of study and research has been done in order to pinpoint the overall functionality of AICAR, up to and including the ways in which it can promote various process, it needs to be emphasized that all of the research has only been constructed around scientific studies that have been based on animal test subjects.  Furthermore, the current use of the peptide is solely intended for scientific research purposes and nothing more.  Any findings or observations relating to AICAR’s overall functionality the determinations that can be derived from such observations should be exclusively contained to a strictly controlled environment such as a laboratory or a medical research facility.